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Acetyl chloride → N-Methyl-N-[1-(benzyl)-4-piperidyl]acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1-benzyl-N-methylpiperidin-4-amine | HCID 4136128 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-Methyl-N-[1-(benzyl)-4-piperidyl]acetamide | HCID 19091417 | — |
反応手順
0.2 mole of acetyl chloride is slowly added to a solution containing 0.2 mole of N-[1-(benzyl)-4-piperidyl]-N-methylamine, 0.2 mole of triethylamine and 500 cm3 of methylene chloride. The mixture is left in contact for 2 hours, evaporated, taken up in ether and then washed with water. After evaporation, an oil which corresponds to the expected compound is obtained:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05208243 |
| 出典データセット | uspto-grants-1993_05 |
| ORD ID | ord-a477921d9c324c70a58a84057190fc6b |
| 出典メモ | uspto-grants-1993_05 |