3,5-Dibromo-4-Hydroxybenzaldehyde → 5-[(3,5-Dibromo-4-hydroxyphenyl)methylene]-2-thioxo-4-imidazolidinone

HRID 247870

反応式

HRID 247870 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Br:11])[C:9]=1[OH:10])[CH:5]=O.[NH:12]1[CH2:18][C:16](=[O:17])[NH:15][C:13]1=[S:14].C([O-])(=O)C.[Na+]>C(O)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:5]=[C:18]2[NH:12][C:13](=[S:14])[NH:15][C:16]2=[O:17])[CH:7]=[C:8]([Br:11])[C:9]=1[OH:10]

参加物

5

反応物 3

HCID 181003,5-Dibromo-4-HydroxybenzaldehydeHCID 517045Sodium AcetateHCID 12740302-Thiohydantoin

生成物 1

HCID 28660855-[(3,5-Dibromo-4-hydroxyphenyl)methylene]-2-thioxo-4-imidazolidinone収率 24.7%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Prepared according to the procedure described in Example 1 using 3,5-dibromo-4-hydroxybenzaldehyde (4.5 g, 16 mmoles), 2-thiohydantoin (1.7 g, 15 mmoles), sodium acetate (4.5 g, 55 mmoles), and acetic acid (35 ml). Recrystallization from ethanol gave the pure product (1.4 g), mp 267° C. (dec).

後処理

  1. customPrepared
  2. customRecrystallization from ethanol

出典と根拠

ORDレコード
ord-91273e9ebc8a4d6f8875ec1ee2435cda
出典データセット
uspto-grants-1993_05
特許番号
US05208250

関連ノート

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