Acetic Acid → 3-(2-Nitroethenyl)thiophene
反応式
[S:1]1[CH:5]=[CH:4][C:3]([CH:6]=O)=[CH:2]1.[N+:8]([CH3:11])([O-:10])=[O:9].C(N)C1C=CC=CC=1.C(O)(=O)C>CC(O)C>[N+:8]([CH:11]=[CH:6][C:3]1[CH:4]=[CH:5][S:1][CH:2]=1)([O-:10])=[O:9]参加物
6
実験手順
When R2 is H the thiophene-3-carboxaldehyde (1 eq) was dissolved in 2-propanol and treated with nitromethane (1 eq), benzylamine (0.065 eq) and glacial acetic acid (0.13 eq). After 60 minutes of refluxing, the mixture was cooled, the solid was collected and washed with ice-cold ether to afford the product (56%); mp 94.5°-96.5° C.
後処理
- temperatureAfter 60 minutes of refluxing
- temperaturethe mixture was cooled
- customthe solid was collected
- washwashed with ice-cold ether
出典と根拠
- ORDレコード
- ord-197ef4f7558e43b9b14b9295f4e89986
- 出典データセット
- uspto-grants-1993_05
- 特許番号
- US05208252
反応ノート
読み込み中…