Hydrochloric Acid → 4-(Tetradecyloxy)benzoic acid

HRID 247912

反応式

HRID 247912 の反応式
C[O:2][C:3](=[O:25])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])=[CH:6][CH:5]=1.[OH-].[K+].Cl>C(Cl)Cl.O.CO.C(O)C>[CH2:11]([O:10][C:7]1[CH:6]=[CH:5][C:4]([C:3]([OH:25])=[O:2])=[CH:9][CH:8]=1)[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]

参加物

8

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 3312490Methyl 4-(tetradecyloxy)benzoate

生成物 1

HCID 2894104-(Tetradecyloxy)benzoic acid収率 99%

試薬・触媒・溶媒 4

HCID 702Ethanol溶媒HCID 887Methanol溶媒2 回HCID 962Water溶媒2 回HCID 6344Dichloromethane溶媒

実験手順

To 20 g of product from Example 1 is added 9.66 g potassium hydroxide, 160 ml methyl alcohol, 10 ml water and 70 ml ethyl alcohol. The reaction mixture is refluxed for 6.5 hours, during which time an additional 100 ml methyl alcohol and 100 ml water is added. To the cooled reaction mixture is added 1 L of methylene chloride and sufficient concentrated hydrochloric acid to make the reaction pH acidic. The white crystals are collected and dried in vacuo over phosphorus pentoxide to give 19.0 g of the desired product. MP 94°-96° C.

後処理

  1. additionis added
  2. customTo the cooled reaction mixture
  3. customThe white crystals are collected
  4. dry with materialdried in vacuo over phosphorus pentoxide

出典と根拠

ORDレコード
ord-1f1a5e5e33ab43668325737b19d38676
出典データセット
uspto-grants-1993_05
特許番号
US05208247

関連ノート

読み込み中…