関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 2-Pyridineethanamine | HCID 75919 | — |
| 反応物 | Benzoyl chloride, 4-(tetradecyloxy)- | HCID 9998158 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-[2-(2-Pyridinyl)ethyl]-4-(tetradecyloxy)benzamide | HCID 10478314 | 41.2% |
反応手順
To a 0° solution of 2.54 g of 2-(2-aminoethyl)pyridine, 50 ml of methylene chloride and 6.42 ml of pyridine is added, dropwise, 7.0 g of product from Example 3 in 250 ml of methylene chloride. The reaction is stirred at 0° C. for 2 hours followed by 14 hours at room temperature. The reaction is diluted with chloroform, washed with saturated sodium bicarbonate, water and saturated sodium chloride, dried and concentrated in vacuo. The residue is purified by column chromatography (silica gel:75-100% ethyl acetate/hexane) to give 3.58 g of the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05208247 |
|---|
| 出典データセット | uspto-grants-1993_05 |
|---|
| ORD ID | ord-3d766805a00346a79f60fb0a4ee3c4ec |
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| 出典メモ | uspto-grants-1993_05 |
|---|
