Hydrochloric Acid → 3,4-Bis(tetradecyloxy)benzoic acid

HRID 248010ノート

反応式

HRID 248010 の反応式
C[O:2][C:3](=[O:40])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])=[C:6]([O:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])[CH:5]=1.[OH-].[K+].O.Cl>C(O)C>[CH2:26]([O:25][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:3]([OH:40])=[O:2])[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 120485573,4-Bis(tetradecyloxy)benzoic acid methyl ester

生成物 1

HCID 190162583,4-Bis(tetradecyloxy)benzoic acid収率 100.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 35 g of product from Example 103, 7.5 g of potassium hydroxide, 30 ml of water and 500 ml of ethyl alcohol is heated at reflux for 24 hours. The reaction is then stirred at room temperature for 48 hours and acidified to pH 2 with concentrated hydrochloric acid. The mixture is concentrated in vacuo, diluted with water and extracted with chloroform. The combined organic layers are washed with saturated sodium chloride, dried and concentrated in vacuo to give 34.2 g of the desired product.

後処理

  1. temperatureis heated
  2. temperatureat reflux for 24 hours
  3. concentrationThe mixture is concentrated in vacuo
  4. additiondiluted with water
  5. extractionextracted with chloroform
  6. washThe combined organic layers are washed with saturated sodium chloride
  7. customdried
  8. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-2b648ebf29584bcfa1919f1fd622cfa9
出典データセット
uspto-grants-1993_05
特許番号
US05208247

反応ノート

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