Potassium Carbonate → HCID 54095197、化合物

HRID 248012

反応式

HRID 248012 の反応式
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6]([OH:11])[CH:5]=1.I[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[C:6]([O:11][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])[CH:5]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 202741-IodoheptaneHCID 287064Methyl 3,4-Dihydroxybenzoate

生成物 1

HCID 54095197HCID 54095197、化合物収率 198.2%

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

A mixture of 25 g of product from Example 102, 72.3 g of 1-iodoheptane, 61.65 g of potassium carbonate and 500 ml of 2-butanone is heated at reflux temperature for 44 hours. The cooled reaction mixture is filtered and concentrated in vacuo. The oily residue is purified by chromatography (silica gel: 10% ethyl acetate/hexane) to give 53.7 g of the desired product.

後処理

  1. temperatureis heated
  2. temperatureat reflux temperature for 44 hours
  3. customThe cooled reaction mixture
  4. filtrationis filtered
  5. concentrationconcentrated in vacuo
  6. customThe oily residue is purified by chromatography (silica gel: 10% ethyl acetate/hexane)

出典と根拠

ORDレコード
ord-6aa4604a96724dc7be7271e866ed0eb3
出典データセット
uspto-grants-1993_05
特許番号
US05208247

関連ノート

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