Ethanol → HCID 19015379、化合物

HRID 248028ノート

反応式

HRID 248028 の反応式
C[O:2][C:3](=[O:25])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[C:6]([C:21]([CH3:24])([CH3:23])[CH3:22])[CH:5]=1.[OH-].[K+].CO.C(O)C>O>[CH2:11]([O:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:25])=[O:2])=[CH:5][C:6]=1[C:21]([CH3:22])([CH3:24])[CH3:23])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]

参加物

6

反応物 4

HCID 702EthanolHCID 887MethanolHCID 14797Potassium HydroxideHCID 539263074-(Decyloxy)-3-(1,1-dimethylethyl)benzoic acid methyl ester

生成物 1

HCID 19015379HCID 19015379、化合物収率 90.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 15.0 g of product from Example 130, 7.24 g of potassium hydroxide, 100 ml methyl alcohol, 40 ml ethyl alcohol and 10 ml of water is heated at reflux temperature for 18 hours. The reaction is cooled to room temperature, made acidic to pH 2, concentrated in vacuo, swirled with water and the solid collected. The solid residue is washed with water and dried in a vacuum oven to give 13 g of the desired product as colorless needles.

後処理

  1. temperatureis heated
  2. temperatureat reflux temperature for 18 hours
  3. concentrationconcentrated in vacuo
  4. customthe solid collected
  5. washThe solid residue is washed with water
  6. customdried in a vacuum oven

出典と根拠

ORDレコード
ord-4b8c05b220b94513880905fce8c955b2
出典データセット
uspto-grants-1993_05
特許番号
US05208247

反応ノート

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