3-Aminobenzonitrile → HCID 178509847、化合物

HRID 24804

反応式

HRID 24804 の反応式
C([N:9]1[C:17]2[C:12](=[CH:13][C:14]([N+:18]([O-:20])=[O:19])=[CH:15][CH:16]=2)[C:11](=[C:21](O)[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:10]1=[O:29])(=O)C1C=CC=CC=1.[NH2:30][C:31]1[CH:32]=[C:33]([CH:36]=[CH:37][CH:38]=1)[C:34]#[N:35]>CN(C=O)C>[C:34]([C:33]1[CH:32]=[C:31]([NH:30]/[C:21](=[C:11]2\[C:10](=[O:29])[NH:9][C:17]3[C:12]\2=[CH:13][C:14]([N+:18]([O-:20])=[O:19])=[CH:15][CH:16]=3)/[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:38]=[CH:37][CH:36]=1)#[N:35]

参加物

4

反応物 2

HCID 167023-AminobenzonitrileHCID 178516550HCID 178516550、化合物

生成物 1

HCID 178509847HCID 178509847、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

2 g (5.2 mmol) of 1-benzoyl-3-(1-hydroxy-1-phenyl-methylidene)-5-nitro-2-indolinone and 1.8 g (16 mmol) of 3-aminobenzonitrile are stirred in DMF for 70 hours at ambient temperature. Then the reaction solution is extracted with ether, the organic phase is washed with water and dried over sodium sulphate. After removal of the solvent in vacuo the residue is chromatographed on silica gel (dichloromethane/methanol=50:1).

後処理

  1. extractionThen the reaction solution is extracted with ether
  2. washthe organic phase is washed with water
  3. dry with materialdried over sodium sulphate
  4. customAfter removal of the solvent in vacuo the residue
  5. customis chromatographed on silica gel (dichloromethane/methanol=50:1)

出典と根拠

ORDレコード
ord-bdb4ef81648c47fd8675561909d34a08
出典データセット
uspto-grants-2005_02
特許番号
US06855710B2

関連ノート

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