Hydrochloric Acid → Diethyl methyl-(4-amino)benzylmalonate

HRID 248063ノート

反応式

HRID 248063 の反応式
[CH3:1][C:2]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20]C(=O)C)=[CH:16][CH:15]=1)([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:3]([O:5][CH2:6][CH3:7])=[O:4].Cl.C(=O)([O-])O>>[CH3:1][C:2]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=1)([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:3]([O:5][CH2:6][CH3:7])=[O:4]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 769Bicarbonate IonHCID 54008305Diethyl methyl-(4-acetamido)benzylmalonate

生成物 1

HCID 54055855Diethyl methyl-(4-amino)benzylmalonate

実験手順

Mix diethyl methyl-(4-acetamido)benzylmalonate (5.01 g, 15.6 mmol) and 2N hydrochloric acid (65 mL) and heat at reflux for several hours. Cool to room temperature, basify with solid hydrogen carbonate and extract into ethyl ether (3×). Dry (MgSO4) and evaporate the solvent in vacuo to give diethyl methyl-(4-amino)benzylmalonate.

後処理

  1. temperatureheat
  2. temperatureat reflux for several hours
  3. extractionextract into ethyl ether (3×)
  4. dry with materialDry (MgSO4)
  5. customevaporate the solvent in vacuo

出典と根拠

ORDレコード
ord-05b0ce8b6270496ab4525a8a2b7e8ddd
出典データセット
uspto-grants-1993_05
特許番号
US05208240

反応ノート

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