関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1,3-Dibromobenzene | HCID 7927 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Iodobenzene | HCID 11575 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Triisopropyl borate | HCID 21531 | — |
| 反応物 | Boronic Acid | HCID 61668 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-Bromobiphenyl | HCID 16449 | — |
反応手順
Starting with readily available starting materials, 1,3-dibromobenzene and the appropriately substituted iodobenzene, it is possible to prepare biphenyls having 3', 4' and 5' position substitution. Referring to Flow Sheet AE 1,3-dibromobenzene AE1 is converted to boronic acid AE2 by first reacting with butyl lithium in anhydrous THF or ether at about -78° C. followed by addition of triisopropyl borate. The resultant intermediate is worked up with sodium hydroxide and acidified. Boronic acid AE2 is subsequently reacted with the appropriate iodobenzene AE3 in toluene and aqueous sodium carbonate with tetrakistriphenylphosphinepalladium as a catalyst to produce the 3-bromo biphenyl B1. This reaction to B1 is well known in art with reference made herein to N. Miyaura, T. Yanagi and A. Suzuki, Syn. Comm., 11, 513 (1981). ##STR19##
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05208329 |
|---|
| 出典データセット | uspto-grants-1993_05 |
|---|
| ORD ID | ord-c162315141934898b8ef634f75735e1c |
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| 出典メモ | uspto-grants-1993_05 |
|---|
