化工社化工社 化学情報印刷レポート · 研究参考用
Water → 3-Hexadecyloxy-2-methylenepropan-1-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 1-Bromohexadecane | HCID 8213 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 2-Butene-1,2-diol | HCID 39605 | — |
| 生成物 | 3-Hexadecyloxy-2-methylenepropan-1-ol | HCID 11358886 | — |
反応手順
To 18.5 g of washed sodium hydride in 500 ml of dry dimethylformamide in a water bath is added dropwise, 67.4 g of 2-butene-1,2-diol. A solution of 235 g of hexadecylbromide in 100 ml of dimethylformamide is added dropwise. This mixture is stirred at room temperature for 2 days then poured into water and extracted with ether. The ether extract is separated, dried, evaporated and purified by chromatography, to give 30 g of the desired compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05208223 |
| 出典データセット | uspto-grants-1993_05 |
| ORD ID | ord-ad49c1303dd048139ab41dea53333574 |
| 出典メモ | uspto-grants-1993_05 |