化工社化工社 化学情報印刷レポート · 研究参考用
Propargyl alcohol → Nonadec-2-yn-1-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Propargyl alcohol | HCID 7859 | — |
| 反応物 | 1-Bromohexadecane | HCID 8213 | — |
| 反応物 | Lithium | HCID 3028194 | — |
| 溶媒 | Ammonia | HCID 222 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Nonadec-2-yn-1-ol | HCID 10967930 | — |
反応手順
A mixture of 56.1 g of propargyl alcohol in 100 ml of tetrahydrofuran and 15.6 g of lithium in 1 liter of ammonia containing a trace of ferric chloride is stirred for 1 hour. A 76.4 ml portion of hexadecyl bromide is added and the mixture refluxed for 8 hours then evaporated. The residue is dissolved in ether and washed with 10% hydrochloric acid, dried and purified by flash chromatography, to give 47.4 g of the desired compound as white platelets, mp. 60° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05208223 |
| 出典データセット | uspto-grants-1993_05 |
| ORD ID | ord-03ad03efdbea4d5a919894b5736fd45f |
| 出典メモ | uspto-grants-1993_05 |