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Ammonia → 2,2-Difluoro-1-Methylcyclopropanecarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 2,2-Difluoro-1-methylcyclopropane-1-carbonyl chloride | HCID 14695232 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2,2-Difluoro-1-Methylcyclopropanecarboxamide | HCID 14695236 | 81% |
反応手順
Gaseous ammonia is passed for 90 minutes into a stirred solution of 15.45 g (0.1 mol) of 2,2-difluoro-1-methyl-cyclopropane-carbonyl chloride in 80 ml of dioxane at 20° to 30° C. The resultant suspension is then evaporated to dryness under a water pump vacuum. The residue remaining is stirred with 50 ml of water, filtered off with suction and dried. In this manner, 11 g (81% of theory) of 2,2-difluoro-1-methyl-cyclopropyl-carboxamide in form of a solid substance of melting point 125°-127° C. are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05208388 |
| 出典データセット | uspto-grants-1993_05 |
| ORD ID | ord-c4c078dec5e3494b98b6169bc5475e93 |
| 出典メモ | uspto-grants-1993_05 |