4-(Trifluoromethyl)phenol → HCID 178521560、化合物

HRID 248303

反応式

HRID 248303 の反応式
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1>[Rh].C(O)C>[F:1][C:2]([F:10])([F:11])[C@H:3]1[CH2:4][CH2:5][C@H:6]([OH:9])[CH2:7][CH2:8]1

参加物

4

反応物 1

HCID 678744-(Trifluoromethyl)phenol

生成物 1

HCID 178521560HCID 178521560、化合物

試薬・触媒・溶媒 2

HCID 23948Rhodium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 0.3 mol of 4-trifluoromethylphenol, 1000 ml of ethanol and 20 g of rhodium/activated charcoal (5%) is hydrogenated for 2 hours at a pressure of 5 bar and a temperature of 60° C. Removal of the solid components by filtration and removal of the solvent by distillation give the cyclohexanol as a cis/trans mixture (30%/70%). From this, the pure trans-compound is obtained by heating with aluminium triisopropylate in toluene in the presence of 3,3-dimethyl-2-butanone and subsequent recrystallization.

後処理

  1. customa temperature of 60° C
  2. customRemoval of the solid components
  3. filtrationby filtration and removal of the solvent
  4. distillationby distillation

出典と根拠

ORDレコード
ord-866de225724b4b2bbc71ba06737524c5
出典データセット
uspto-grants-1993_05
特許番号
US05209868

関連ノート

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