Hydrochloric Acid → HCID 178520943、化合物

反応式

[F:1][C:2]([F:13])([F:12])[C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9](O)=[O:10])[CH2:5][CH2:4]1.C([Mg]Br)C(C)C.CCOCC.Cl>>[F:1][C:2]([F:12])([F:13])[C@H:3]1[CH2:4][CH2:5][C@H:6]([CH:9]=[O:10])[CH2:7][CH2:8]1

参加物

反応物 4

HCID 313Hydrochloric Acid

HCID 3283Diethyl Ether

HCID 178418816HCID 178418816、化合物

HCID 178525710HCID 178525710、化合物

生成物 1

HCID 178520943HCID 178520943、化合物

実験手順

0.05 mol of trans-4-trifluoromethylcyclohexanecarboxylic acid (prepared as in Example 1) is added dropwise to 100 ml of a solution of isobutylmagnesium bromide in ether (1 mol/1) and 0.3 mmol of dichlorobis[π-cyclopentadienyl]titanium at 0° C., and the mixture is stirred at room temperature for 4 hours. 30 ml of a 4 normal hydrochloric acid are added, and customary workup gives the product as a colourless oil.