HCID 15670106、化合物 → 4-[(5-Chloro-2-methoxyphenoxy)methyl]-1-piperidinepropanamine hydrochloride

HRID 248346ノート

反応式

HRID 248346 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:39][CH3:40])=[C:6]([CH:38]=1)[O:7][CH2:8][CH:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18]C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:11][CH2:10]1>CO>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:39][CH3:40])=[C:6]([CH:38]=1)[O:7][CH2:8][CH:9]1[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][CH2:17][NH2:18])[CH2:13][CH2:14]1

参加物

3

反応物 1

HCID 15670106HCID 15670106、化合物

生成物 1

HCID 197633664-[(5-Chloro-2-methoxyphenoxy)methyl]-1-piperidinepropanamine hydrochloride収率 84.9%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
0 °C

実験手順

9.5 g (0.017 mol) of 4-[(5-chloro-2-methoxyphenoxy)methyl]-N-(triphenylmethyl)-1-piperidinepropanamine are suspended in 215 ml of methanol. The reaction mixture is cooled to 0° C. and gaseous hydrochloric acid is bubbled in. The reaction mixture is allowed to return to room temperature and is evaporated to dryness, and the product obtained is recrystallised in an MeOH/AcOEt (50 ml:150 ml) mixture. Yield: 84.9%, M.p. 153°-157° C.

後処理

  1. customgaseous hydrochloric acid is bubbled in
  2. customto return to room temperature
  3. customis evaporated to dryness
  4. customthe product obtained
  5. customis recrystallised in an MeOH/AcOEt (50 ml:150 ml) mixture

出典と根拠

ORDレコード
ord-9d9b43bfd5b548ac919601e45d9f3a41
出典データセット
uspto-grants-1993_05
特許番号
US05210086

反応ノート

読み込み中…