関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | (2-Bromoethyl)tritylamine | HCID 15718287 | — |
| 反応物 | 4-[(4,5-Difluoro-2-methoxyphenoxy)methyl]piperidine hydrochloride | HCID 19763367 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-[(4,5-Difluoro-2-methoxyphenoxy)methyl]-N-(triphenylmethyl)-1-piperidineethanamine | HCID 19763385 | 41.5% |
反応手順
5.88 g (0.020 mol) of 4-[(4,5-difluoro-2-methoxyphenoxy)methyl]piperidine hydrochloride, 7.7 g (0.021 mol) of 2-bromo-N-(triphenylmethyl)ethylamine and 6.91 g (0.050 mol) of K2CO3 in 40 ml of DMF are reacted. The reaction mixture is heated to 90° C. for 8 hours. It is cooled to room temperature, poured into 500 ml of water and extracted 3 times with ethyl acetate. The organic phases are combined, washed with water, dried over MgSO4 and filtered, and the solvent is evaporated off under reduced pressure. The product is obtained in the form of an oil after chromatography. Yield: 41.5%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05210086 |
|---|
| 出典データセット | uspto-grants-1993_05 |
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| ORD ID | ord-d32e64f01da745f7a4d7dbc8a579c938 |
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| 出典メモ | uspto-grants-1993_05 |
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