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Trimethyl orthovalerate → 2-butyl-1H-thieno[3,4-d]imidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trimethyl orthovalerate | HCID 83755 | — |
| 反応物 | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| 反応物 | Thiophene-3,4-diamine | HCID 643216 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-butyl-1H-thieno[3,4-d]imidazole | HCID 19370634 | — |
反応手順
To a solution of 3,4-diaminothiophene (156 mg) in ethanol (10 ml) was added trimethyl orthovalerate (0.29 ml) and pyridinium p-toluenesulfonate (4 mg). The mixture was refluxed for one hour and concentrated in vacuo. The residue was purified by preparative thin layer chromatography on silica gel developed by ethyl acetate to give 2-butyl-1H-thieno[3,4-d]imidazole (155 mg) as crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05210092 |
| 出典データセット | uspto-grants-1993_05 |
| ORD ID | ord-354f919044724ce2b749849551db4a26 |
| 出典メモ | uspto-grants-1993_05 |