関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Trifluoroacetate | HCID 517019 | — |
| 反応物 | 1-(4-Methylphenyl)-4-bromo-2-cyanopyrrole | HCID 18956250 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 1-(4-Methylphenyl)-4-trifluoromethylpyrrole-2-carbonitrile | HCID 19759270 | 27.9% |
反応手順
A mixture of 4-bromo-1-(4-methylphenyl)pyrrole-2-carbonitrile (3.66 g), sodium trifluoroacetate (7.62 g), cuprous iodide (5.34 g) and N-methylpyrrolidone (40 ml) was stirred at 200° C. under a nitrogen atmosphere for 11 hours. The mixture was filtered. The filtrate was poured into water and extracted with ethyl acetate twice. The combined organic layer was dried over magnesium sulfate and evaporated in vacuo. The residue was purified by silica gel column chromatography to afford 1-(4-methylphenyl)-4-trifluoromethylpyrrole-2-carbonitrile (0.98 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05210092 |
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| 出典データセット | uspto-grants-1993_05 |
|---|
| ORD ID | ord-5d9592eed04d4b8b9906eed4eb778fa5 |
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| 出典メモ | uspto-grants-1993_05 |
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