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Fluoroquinolonic acid → 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[3-(phenoxymethyl)-1-piperazinyl]-3-quinolinecarboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Fluoroquinolonic acid | HCID 483180 | — |
| 反応物 | 3-Phenoxymethylpiperazine | HCID 19763604 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[3-(phenoxymethyl)-1-piperazinyl]-3-quinolinecarboxylic acid | HCID 14839407 | — |
反応手順
A 0.6 g portion of 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, 1.23 g of 3-(phenoxymethyl)piperazine and 5 ml of pyridine were reacted as described in Example 81, giving 235 mg of the desired product, mp 112°-115° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05210193 |
| 出典データセット | uspto-grants-1993_05 |
| ORD ID | ord-60bd551670914408ab036a718445de43 |
| 出典メモ | uspto-grants-1993_05 |