化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → 2-[2-[N-(4-Fluoro-2-trifluoromethylphenyl)sulfamoyl]acetylamino]-2-hydroxymethylacetic Acid Methyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | L-Serine, methyl ester, hydrochloride (1:1) | HCID 2723730 | — |
| 反応物 | 2-[N-(4-fluoro-2-trifluoromethylphenyl)sulfamoyl]acetic acid | HCID 15676555 | — |
| 反応物 | HCID 178526939 | HCID 178526939 | — |
| 生成物 | 2-[2-[N-(4-Fluoro-2-trifluoromethylphenyl)sulfamoyl]acetylamino]-2-hydroxymethylacetic Acid Methyl Ester | HCID 15676558 | — |
反応手順
Under the conditions of Example 2(a), 3.29 g (10.93 mmol) of 2-[N-(4-fluoro-2-trifluoromethylphenyl)sulfamoyl]acetic acid, 1.70 g (10.93 mmol) L-serine methyl ester hydrochloride, 1.67 g (10.93 mmol) of hydroxybenzotriazole, hydrate, as well as 1.11 g (10.93 mmol) of triethylamine and 2.26 g (10.93 mmol) of dicyclohexylcarbodiimide are reacted and worked up analogously. The crude product is chromatographed on silica gel. The title compound is eluted with ethanol and crystallized upon concentration.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05210290 |
| 出典データセット | uspto-grants-1993_05 |
| ORD ID | ord-9e464e8c790a4afc8007593b85eaa8fa |
| 出典メモ | uspto-grants-1993_05 |