Triethylamine → 2-[2-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]benzoylamino]-2-methylacetic Acid Ethyl Ester

HRID 248722ノート

反応式

HRID 248722 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][S:9]([C:12]2[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=2[C:14](O)=[O:15])(=[O:11])=[O:10])=[CH:4][C:3]=1[C:21]([F:24])([F:23])[F:22].Cl.[CH2:26]([O:28][C:29](=[O:33])[C@H:30]([CH3:32])[NH2:31])[CH3:27].O.OC1C2N=NNC=2C=CC=1.C(N(CC)CC)C.C1(N=C=NC2CCCCC2)CCCCC1>>[CH2:26]([O:28][C:29](=[O:33])[CH:30]([NH:31][C:14](=[O:15])[C:13]1[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=1[S:9](=[O:11])(=[O:10])[NH:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[C:3]([C:21]([F:22])([F:23])[F:24])[CH:4]=1)[CH3:32])[CH3:27]

参加物

6

反応物 5

HCID 8471TriethylamineHCID 10868DicyclohexylcarbodiimideHCID 2724356L-Alanine, ethyl ester, hydrochloride (1:1)HCID 197640052-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl]benzoic acidHCID 178526939HCID 178526939、化合物

生成物 1

HCID 156765722-[2-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]benzoylamino]-2-methylacetic Acid Ethyl Ester

実験手順

Under the conditions of Example 2(a), 3.633 g (10 mmol) of 2-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl]benzoic acid, 1.536 g (10 mmol) of L-alanine ethyl ester hydrochloride, 1.531 g (10 mmol) of hydroxybenzotriazole, hydrate, as well as 1.012 g (10 mmol) of triethylamine and 2.063 g (10 mmol) of dicyclohexylcarbodiimide are reacted and worked up analogously. The crude product is chromatographed on silica gel. The title compound is eluted with ethyl acetate.

後処理

  1. customThe crude product is chromatographed on silica gel
  2. washThe title compound is eluted with ethyl acetate

出典と根拠

ORDレコード
ord-122baeec85d74bb0b66ece207cb0c40a
出典データセット
uspto-grants-1993_05
特許番号
US05210290

反応ノート

読み込み中…