Triethylamine → 3-[2-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]acetylamino]-3-methoxycarbonylpropionic Acid Methyl Ester

HRID 248727ノート

反応式

HRID 248727 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][S:9]([CH2:12][C:13]([OH:15])=O)(=[O:11])=[O:10])=[CH:4][C:3]=1[C:16]([F:19])([F:18])[F:17].Cl.[CH3:21][O:22][C:23](=[O:31])[C@H:24]([CH2:26][C:27]([O:29][CH3:30])=[O:28])[NH2:25].O.OC1C2N=NNC=2C=CC=1.C(N(CC)CC)C.C1(N=C=NC2CCCCC2)CCCCC1>>[CH3:30][O:29][C:27](=[O:28])[CH2:26][CH:24]([NH:25][C:13](=[O:15])[CH2:12][S:9](=[O:10])(=[O:11])[NH:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[C:3]([C:16]([F:19])([F:18])[F:17])[CH:4]=1)[C:23]([O:22][CH3:21])=[O:31]

参加物

6

反応物 5

HCID 8471TriethylamineHCID 10868DicyclohexylcarbodiimideHCID 2734892L-Aspartic acid, 1,4-dimethyl ester, hydrochloride (1:1)HCID 197640082-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl]acetic acidHCID 178526939HCID 178526939、化合物

生成物 1

HCID 156765783-[2-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]acetylamino]-3-methoxycarbonylpropionic Acid Methyl Ester

実験手順

Under the conditions of Example 2(a), 3.012 g (10 mmol) of 2-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl]acetic acid, 1.836 g (10 mmol) of L-aspartic acid dimethyl ester hydrochloride, 1.531 g (10 mmol) of hydroxybenzotriazole, hydrate, as well as 1.012 g (10 mmol) of triethylamine and 2.063 g (10 mmol) of dicyclohexylcarbodiimide are reacted and worked up analogously. The crude product is chromatographed on silica gel. The title compound is eluted with ethyl acetate.

後処理

  1. customThe crude product is chromatographed on silica gel
  2. washThe title compound is eluted with ethyl acetate

出典と根拠

ORDレコード
ord-959443e4a2544ca28c34658ea6fe4ed9
出典データセット
uspto-grants-1993_05
特許番号
US05210290

反応ノート

読み込み中…