Triethylamine → 3-[2-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]acetylamino]propionic Acid Ethyl Ester
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][S:9]([CH2:12][C:13]([OH:15])=O)(=[O:11])=[O:10])=[CH:4][C:3]=1[C:16]([F:19])([F:18])[F:17].[OH2:20].[OH:21][C:22]1[C:30]2N=N[NH:27][C:26]=2C=CC=1.C(N([CH2:36][CH3:37])CC)C.C1(N=C=NC2CCCCC2)CCCCC1>>[CH2:36]([O:20][C:22](=[O:21])[CH2:30][CH2:26][NH:27][C:13](=[O:15])[CH2:12][S:9](=[O:10])(=[O:11])[NH:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[C:3]([C:16]([F:19])([F:18])[F:17])[CH:4]=1)[CH3:37]参加物
5
実験手順
Under the conditions of Example 2(a), 3.012 g (10 mmol) of 2-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl]acetic acid, 1.536 g (10 mmol) of β-alanine ethyl acid dimethyl ester hydrochloride, 1.531 g (10 mmol) of hydroxybenzotriazole, hydrate, as well as 1.012 g (10 mmol) of triethylamine and 2.063 g (10 mmol) of dicyclohexylcarbodiimide are reacted and worked up analogously. The crude product is chromatographed on silica gel. The title compound is eluted with ethyl acetate.
後処理
- customThe crude product is chromatographed on silica gel
- washThe title compound is eluted with ethyl acetate
出典と根拠
- ORDレコード
- ord-8029a948a8d345fc911aa3ebbc6f9cef
- 出典データセット
- uspto-grants-1993_05
- 特許番号
- US05210290
反応ノート
読み込み中…