Triethylamine → 3-[4-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]benzoylamino]propionic Acid Ethyl Ester

HRID 248738ノート

反応式

HRID 248738 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][S:9]([C:12]2[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=2C(O)=O)(=[O:11])=[O:10])=[CH:4][C:3]=1[C:21]([F:24])([F:23])[F:22].Cl.[CH2:26]([O:28][C:29](=[O:33])[CH2:30][CH2:31][NH2:32])[CH3:27].O.[OH:35][C:36]1C2N=NNC=2C=CC=1.C(N(CC)CC)C.C1(N=C=NC2CCCCC2)CCCCC1>>[CH2:26]([O:28][C:29](=[O:33])[CH2:30][CH2:31][NH:32][C:36](=[O:35])[C:18]1[CH:17]=[CH:13][C:12]([S:9](=[O:10])(=[O:11])[NH:8][C:5]2[CH:6]=[CH:7][C:2]([F:1])=[C:3]([C:21]([F:24])([F:23])[F:22])[CH:4]=2)=[CH:20][CH:19]=1)[CH3:27]

参加物

6

反応物 5

HCID 8471TriethylamineHCID 10868DicyclohexylcarbodiimideHCID 458475beta-Alanine, ethyl ester, hydrochlorideHCID 197640052-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl]benzoic acidHCID 178526939HCID 178526939、化合物

生成物 1

HCID 540932793-[4-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]benzoylamino]propionic Acid Ethyl Ester

実験手順

Under the conditions of Example 2(a), 3.633 g (10 mmol) of 2-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl]benzoic acid, 1.536 g (10 mmol) of β-alanine ethyl ester hydrochloride, 1.531 g (10 mmol) of hydroxybenzotriazole, hydrate, as well as 1.012 g (10 mmol) of triethylamine and 2.063 g (10 mmol) of dicyclohexylcarbodiimide are reacted and worked up in analogous fashion. The crude product is chromatographed on silica gel. The title compound is eluted with ethyl acetate.

後処理

  1. customThe crude product is chromatographed on silica gel
  2. washThe title compound is eluted with ethyl acetate

出典と根拠

ORDレコード
ord-58e8d20523884b67a8e827c90e18ec2b
出典データセット
uspto-grants-1993_05
特許番号
US05210290

反応ノート

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