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4-Methylmorpholine → Glycine,n-(1-oxo-3-phenyl-2-propen-1-yl)-, methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Methylmorpholine | HCID 7972 | — |
| 反応物 | 2-Propenoic acid, 3-phenyl- | HCID 8784 | — |
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 反応物 | Glycine methyl ester hydrochloride | HCID 122755 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Glycine,n-(1-oxo-3-phenyl-2-propen-1-yl)-, methyl ester | HCID 582979 | — |
反応手順
Cinnamic acid (38.0 g) was coupled to glycine methyl ester hydrochloride in dimethylformamide by treatment with dicyclohexylcarbodiimide (52.84 g) and 1-hydroxybenzotriazole (39.24 g), followed by N-methylmorpholine (37.56 ml). The reaction mixture was stirred overnight at room temperature and then worked up in the usual manner to give the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05212158 |
| 出典データセット | uspto-grants-1993_05 |
| ORD ID | ord-ecf315e47df3405c9faf417599866d90 |
| 出典メモ | uspto-grants-1993_05 |