関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzoic Acid | HCID 243 | — |
| 反応物 | 4-Methylmorpholine | HCID 7972 | — |
| 反応物 | Isobutyl chloroformate | HCID 62365 | — |
| 反応物 | Glycine tert-butyl ester | HCID 151417 | — |
| 反応物 | Glycine,n-(1-oxo-3-phenyl-2-propen-1-yl)-, methyl ester | HCID 582979 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Benzoyl-glycine-t-butyl ester | HCID 11020853 | — |
反応手順
Following the same general procedure described previously for cinnamoyl-glycine-methyl ester, glycine-t-butyl ester. MCl (10.88 grams) was dissolved in dimethyl formamide (approximately 100 ml), cooled to 0° C. and treated with N-methylmorpholine (9.04 ml, 1 equivalent) followed immediately by a pre-cooled solution of benzoic acid (7.94 grams) in ethyl acetate (approximately 75 ml) which had been pre-activated by treatment with N-methylmorpholine (9.04 ml) followed by isobutyl chloroformate (8.4 ml) at -20° C. After work-up, benzoyl-glycine-t-butyl ester was obtained as a white solid which was used for the next step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05212158 |
|---|
| 出典データセット | uspto-grants-1993_05 |
|---|
| ORD ID | ord-4d01de82081c4a869f6b99e9d83ef640 |
|---|
| 出典メモ | uspto-grants-1993_05 |
|---|
