化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Phenylacetyl-glycine-t-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Phenylacetic Acid | HCID 999 | — |
| 反応物 | 4-Methylmorpholine | HCID 7972 | — |
| 反応物 | Isobutyl chloroformate | HCID 62365 | — |
| 反応物 | Glycine tert-butyl ester | HCID 151417 | — |
| 反応物 | Benzoyl-glycine-t-butyl ester | HCID 11020853 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Phenylacetyl-glycine-t-butyl ester | HCID 19762247 | — |
反応手順
Following the procedure described for benzoyl-glycine-t-butyl ester, a solution of phenylacetic acid (11.44 grams) in ethyl acetate (approx. 100 ml) was activated by the mixed anhydride method using N-methylmorpholine (11.66 ml) followed by isobutyl chloroformate (10.89 ml) at -20° C. and coupled with glycine t-butyl ester.HCl (14.04 g) in methylene chloride (approx. 150 ml) which had been neutralized by addition of N-methylmorpholine (11.66 ml). After work-up, the product was obtained as an oil which was used for the next step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05212158 |
| 出典データセット | uspto-grants-1993_05 |
| ORD ID | ord-788a972defb74bada23a51c3657af5e9 |
| 出典メモ | uspto-grants-1993_05 |