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HRID 248901作成日：2026年10月25日

N-(((1-(2-Naphthalenylmethyl)-4-piperidinyl)amino)carbonyl)benzamide → [1-(Naphth-2-ylmethyl)piperid-4-yl]urea

https://huagongshe.com/reaction/248901

反応式

関与物質

役割名称HCID仕込み量
反応物N-(((1-(2-Naphthalenylmethyl)-4-piperidinyl)amino)carbonyl)benzamideHCID 72002—
溶媒Sodium HydroxideHCID 14798—
生成物[1-(Naphth-2-ylmethyl)piperid-4-yl]ureaHCID 13145794—

反応手順

1-Benzoyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]urea (prepared according to Example 1) is hydrolysed by refluxing in 2N sodium hydroxide to give [1-(naphth-2-ylmethyl)piperid-4-yl]urea(m.p. 183°-5° C.). The product is acylated by reaction with 4-methoxybenzoyl chloride to give the title compound, m.p. of HCl, quarterhydrate=193°-193.5° C.).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US05212179
出典データセットuspto-grants-1993_05
ORD IDord-471cc0bfbc9b40e7b7522546f7f5128a
出典メモuspto-grants-1993_05