HCID 19762593、化合物 → HCID 178484315、化合物

HRID 248943ノート

反応式

HRID 248943 の反応式
[CH3:1][N:2]([CH2:6][CH2:7][CH:8]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1)[CH2:3][CH2:4][NH2:5].[C:21]([NH:23][C:24](=[N:32][CH2:33][CH2:34][S:35][CH2:36][C:37]1[N:38]=[C:39]([NH:42][C:43]([NH2:45])=[NH:44])[S:40][CH:41]=1)OC1C=CC=CC=1)#[N:22]>>[C:21]([NH:23][C:24]([NH:32][CH2:33][CH2:34][S:35][CH2:36][C:37]1[N:38]=[C:39]([NH:42][C:43]([NH2:45])=[NH:44])[S:40][CH:41]=1)=[N:5][CH2:4][CH2:3][N:2]([CH2:6][CH2:7][CH:8]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1)[CH3:1])#[N:22]

参加物

3

反応物 2

HCID 19762593HCID 19762593、化合物HCID 178512334HCID 178512334、化合物

生成物 1

HCID 178484315HCID 178484315、化合物

実験手順

Preparation is effected analogously to Example 1, using 0.8 g (3 mmol) of N-methyl-N-[3-phenyl-3-(2-pyridyl)propyl]-1,2-ethanediamine and 1.01 g (2.7 mmol) of N-cyano-N'-[2-[[(2-guanidino-4-thiazolyl)methyl]thio]ethyl]-O-phenyl-isourea as starting materials. Working up by chromatography analogously to Example 1 yields the purified title compound in the form of a viscous oil; MS (+FAB method): m/z (rel. int.[%])=551 ([M+H]+, 2), 196 (100); IR (KBr): 2164 cm-1 (C≡N). For analytical purposes a sample is converted into the maleic acid salt and recrystallised from ether/ethanol; m.p.: 115°-116° C. with decomposition.

後処理

  1. customPreparation
  2. customWorking up by chromatography analogously to Example 1 yields the
  3. custompurified title compound in the form of a viscous oil
  4. customrecrystallised from ether/ethanol

出典と根拠

ORDレコード
ord-57091491603e41a982f0d9f8af600ed9
出典データセット
uspto-grants-1993_05
特許番号
US05212187

反応ノート

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