関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Urea | HCID 1176 | — |
| 反応物 | 3-Aminopyridine-2-carbonitrile | HCID 577015 | — |
| 溶媒 | Diethylene Glycol Monoethyl Ether | HCID 8146 | — |
| 生成物 | 4-Amino-pyrido[2,3-e]pyrimidin-2-one | HCID 19366879 | — |
反応手順
A slurry of 3-Amino-2-cyanopyridine (200 mg) and urea (400 mg) in 2-(2-ethoxyethoxy)ethanol (0.5 mL) was gradually heated to about 205° C., and maintained at 205° C. for 10 min. Heating was ceased and 6 mL of hot water was carefully added while shaking the mixture. The mixture was vacuum filtered to collect the precipitate. The precipitate was washed with water and ethyl acetate and allowed to dry to yield 4-Amino-pyrido[2,3-e]pyrimidin-2-one as a light yellow solid, m.p. >300° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05212310 |
|---|
| 出典データセット | uspto-grants-1993_05 |
|---|
| ORD ID | ord-8c8abec0a7934af8a15f606f2ba90a6a |
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| 出典メモ | uspto-grants-1993_05 |
|---|
