Sulfuric Acid → 5-Acetyl-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

HRID 249084ノート

反応式

HRID 249084 の反応式
S(=O)(=O)(O)[OH:2].[C:6]([C:9]1[CH:10]=[C:11]([C:17]#[N:18])[C:12](=[O:16])[NH:13][C:14]=1[CH3:15])(=[O:8])[CH3:7]>>[C:6]([C:9]1[CH:10]=[C:11]([C:17]([NH2:18])=[O:2])[C:12](=[O:16])[NH:13][C:14]=1[CH3:15])(=[O:8])[CH3:7]

参加物

3

反応物 2

HCID 1118Sulfuric AcidHCID 27654765-Acetyl-2-hydroxy-6-methylnicotinonitrile

生成物 1

HCID 27644175-Acetyl-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

反応条件

温度
60 °C

実験手順

To 100 grams of concentrated sulfuric acid is added 10 g (0.056 mole) of 5-acetyl-1,2-dihydro-6-methyl2-oxo-3-pyridinecarbonitrile. The mixture is stirred at 60° C. for 5 hours, cooled and then poured on 1 kg ice. The resulting solid is collected, washed with water and recrystallized from ethanol to give the title compound.

後処理

  1. temperaturecooled
  2. customThe resulting solid is collected
  3. washwashed with water
  4. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-9a931bb715594d5fb802a2e3d32f45a5
出典データセット
uspto-grants-1993_05
特許番号
US05212314

反応ノート

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