Isobutylbenzene → 4'-Isobutylhexanophenone

HRID 249183

反応式

HRID 249183 の反応式
[Cl-].[Al+3].[Cl-].[Cl-].[C:5](Cl)(=[O:11])[CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[CH2:13]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH:14]([CH3:16])[CH3:15]>ClCCl>[CH2:13]([C:17]1[CH:22]=[CH:21][C:20]([C:5](=[O:11])[CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])=[CH:19][CH:18]=1)[CH:14]([CH3:16])[CH3:15]

参加物

5

反応物 3

HCID 10870IsobutylbenzeneHCID 67340Hexanoyl chlorideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 108790194'-Isobutylhexanophenone

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

To a suspension of aluminum chloride (6.67 g) in dichloromethane (70 ml) was added hexanoyl chloride (7.0 ml) at 0° C. After the mixture was stirred at 0° C. for 15 minutes, isobutylbenzene (7.9 ml) was added to the mixture. The mixture was stirred at 0° C. for 30 minutes and poured into ice water. The separated organic layer was washed with water, aqueous sodium bicarbonate and brine. The solution was dried over magnesium sulfate and evaporated to give 4'-isobutylhexanophenone (10.52 g) as a colorless oil.

後処理

  1. stirringThe mixture was stirred at 0° C. for 30 minutes
  2. washThe separated organic layer was washed with water, aqueous sodium bicarbonate and brine
  3. dry with materialThe solution was dried over magnesium sulfate
  4. customevaporated

出典と根拠

ORDレコード
ord-deb06ca4e0e64b41a5ca817defb57461
出典データセット
uspto-grants-1993_05
特許番号
US05212320

関連ノート

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