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Potassium Carbonate → 4-(4-Nitro-benzyl)-thiomorpholine 1,1-dioxide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Nitrobenzyl bromide | HCID 66011 | — |
| 反応物 | Thiomorpholine 1,1-dioxide | HCID 6484228 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 4-(4-Nitro-benzyl)-thiomorpholine 1,1-dioxide | HCID 22569762 | — |
反応手順
8.6 g (40 mmol) of 4-nitrobenzylbromide are dissolved in 100 ml of acetone. 6.9 g (50 mmol) of potassium carbonate and 5.4 g (40 mmol) of thiomorpholine-1,1-dioxide are added. The reaction solution is stirred for 7 hours at ambient temperature. After the undissolved solids have been filtered off, the solution is concentrated by evaporation. The residue is divided between ethyl acetate and water. The organic phases are freed from solvent in vacuo. The product is triturated with ether and dried.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06855710B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-b6d7314026c24c77bd7ca76677a3d6c5 |
| 出典メモ | uspto-grants-2005_02 |