Potassium Carbonate → 4-(4-Nitro-benzyl)-thiomorpholine 1,1-dioxide

HRID 24919

反応式

HRID 24919 の反応式
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Br)=[CH:6][CH:5]=1)([O-:3])=[O:2].C(=O)([O-])[O-].[K+].[K+].[NH:18]1[CH2:23][CH2:22][S:21](=[O:25])(=[O:24])[CH2:20][CH2:19]1>CC(C)=O>[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8][N:18]2[CH2:23][CH2:22][S:21](=[O:25])(=[O:24])[CH2:20][CH2:19]2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 660114-Nitrobenzyl bromideHCID 6484228Thiomorpholine 1,1-dioxide

生成物 1

HCID 225697624-(4-Nitro-benzyl)-thiomorpholine 1,1-dioxide

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

8.6 g (40 mmol) of 4-nitrobenzylbromide are dissolved in 100 ml of acetone. 6.9 g (50 mmol) of potassium carbonate and 5.4 g (40 mmol) of thiomorpholine-1,1-dioxide are added. The reaction solution is stirred for 7 hours at ambient temperature. After the undissolved solids have been filtered off, the solution is concentrated by evaporation. The residue is divided between ethyl acetate and water. The organic phases are freed from solvent in vacuo. The product is triturated with ether and dried.

後処理

  1. filtrationAfter the undissolved solids have been filtered off
  2. concentrationthe solution is concentrated by evaporation
  3. customThe product is triturated with ether
  4. customdried

出典と根拠

ORDレコード
ord-b6d7314026c24c77bd7ca76677a3d6c5
出典データセット
uspto-grants-2005_02
特許番号
US06855710B2

関連ノート

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