Hydrochloric Acid → N-methyl-4-nitrophenethylamine
反応式
[CH3:1][NH2:2].Br[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1.Cl>ClCCl.O>[CH3:1][NH:2][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1参加物
6
実験手順
2.7 g (86 mmol) of methylamine are dissolved in 120 ml of dichloromethane while cooling with ice. 4.9 g (21 mmol) of 4-(2-bromoethyl)-nitrobenzene are added and the mixture is allowed to come up slowly to ambient temperature. After 15 hours stirring the solvent is eliminated in vacuo and the residue taken up in water. An acid pH is created using 2 N hydrochloric acid and the mixture is washed with dichloromethane. The aqueous phase is then adjusted to a basic pH using 4 N sodium hydroxide solution and the product is extracted with dichloromethane.
後処理
- temperaturewhile cooling with ice
- customto come up slowly to ambient temperature
- washthe mixture is washed with dichloromethane
- extractionthe product is extracted with dichloromethane
出典と根拠
- ORDレコード
- ord-0770d44e24ec4c24a921ae9eccf562c9
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06855710B2
反応ノート
読み込み中…