Hydrochloric Acid → N-methyl-4-nitrophenethylamine

HRID 24920

反応式

HRID 24920 の反応式
[CH3:1][NH2:2].Br[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1.Cl>ClCCl.O>[CH3:1][NH:2][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 6329MethylamineHCID 792664-Nitrophenethyl bromide

生成物 1

HCID 2794239N-methyl-4-nitrophenethylamine

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒

実験手順

2.7 g (86 mmol) of methylamine are dissolved in 120 ml of dichloromethane while cooling with ice. 4.9 g (21 mmol) of 4-(2-bromoethyl)-nitrobenzene are added and the mixture is allowed to come up slowly to ambient temperature. After 15 hours stirring the solvent is eliminated in vacuo and the residue taken up in water. An acid pH is created using 2 N hydrochloric acid and the mixture is washed with dichloromethane. The aqueous phase is then adjusted to a basic pH using 4 N sodium hydroxide solution and the product is extracted with dichloromethane.

後処理

  1. temperaturewhile cooling with ice
  2. customto come up slowly to ambient temperature
  3. washthe mixture is washed with dichloromethane
  4. extractionthe product is extracted with dichloromethane

出典と根拠

ORDレコード
ord-0770d44e24ec4c24a921ae9eccf562c9
出典データセット
uspto-grants-2005_02
特許番号
US06855710B2

関連ノート

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