(-)-(2S,3R)-1-butyroxy-2,3-epoxy-8-methylnonane → (-)-(2S,3R)-2,3-epoxy-8-methyl-1-nonanol

反応式

C([O:6][CH2:7][C@@H:8]1[O:17][C@@H:9]1[CH2:10][CH2:11][CH2:12][CH2:13][CH:14]([CH3:16])[CH3:15])(=O)CCC.[OH-].[K+].CO>>[O:17]1[C@H:9]([CH2:10][CH2:11][CH2:12][CH2:13][CH:14]([CH3:16])[CH3:15])[C@@H:8]1[CH2:7][OH:6]

参加物

反応物 2

HCID 18651942(-)-(2S,3R)-1-butyroxy-2,3-epoxy-8-methylnonane

HCID 23689386Potassium hydroxide methanol

生成物 1

HCID 14102158(-)-(2S,3R)-2,3-epoxy-8-methyl-1-nonanol収率 93.8%

実験手順

3.6 g of (-)-(2S,3R)-1-butyroxy-2,3-epoxy-8-methylnonane was hydrolyzed with potassium hydroxide/methanol to yield 2.4 g of (-)-(2S,3R)-2,3-epoxy-8-methyl-1-nonanol.

出典と根拠

ORDレコード: ord-4176ab5b2d544d5ebf274ed33664a499
出典データセット: uspto-grants-1993_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05213975

反応ノート

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