化工社化工社 化学情報印刷レポート · 研究参考用
Anthranilic Acid → 1,2,3,3a-Tetrahydro-3a-phenyl-5H-pyrrolo[1,2-a]-3,1-benzoxazin-5-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Anthranilic Acid | HCID 227 | — |
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | 4-Chlorobutyrophenone | HCID 253533 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 生成物 | 1,2,3,3a-Tetrahydro-3a-phenyl-5H-pyrrolo[1,2-a]-3,1-benzoxazin-5-one | HCID 19761077 | — |
反応手順
A mixture of 26.1 g of 2-aminobenzoic acid, 36.5 g of 4-chloro-1-phenyl-1-butanone, 0.5 g of p-toluenesulfonic acid and 250 ml of xylene were refluxed with a water trap. After the reaction was complete, the solvent was removed by distillation and the remaining solid was recrystallized from ethanol. Yield: 41.1 g (81.5%), melting point 152° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05214047 |
| 出典データセット | uspto-grants-1993_05 |
| ORD ID | ord-db75a1b05ccf4cf8acdc118e9f3e2955 |
| 出典メモ | uspto-grants-1993_05 |