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2-Methylanisole → 4-Bromo-1-methoxy-2-methylbenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methylanisole | HCID 33637 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 触媒 | Benzoyl Peroxide | HCID 7187 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | 4-Bromo-1-methoxy-2-methylbenzene | HCID 608315 | 47.1% |
反応手順
A solution of 24 g of 2-methylanisole, 35 g of N-bromosuccinimide and 1.24 g of dibenzoyl peroxide in 150 ml of carbon tetrachloride was heated to boiling under reflux for 12 hours. After cooling the solution was filtered and the filtrate is evaporated. The residue was recrystallized from hexane. There were obtained 18.6 g (47%) of 4-bromo-2-methylanisole as a colorless solid; m.p. 66°-68°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05214046 |
| 出典データセット | uspto-grants-1993_05 |
| ORD ID | ord-e726e1f3800646a79b1e16dd269c2994 |
| 出典メモ | uspto-grants-1993_05 |