Phenacylamine → 2-Aminoacetophenone 4-chlorophenylhydrazone

HRID 249317ノート

反応式

HRID 249317 の反応式
[NH2:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18][NH2:19])=[CH:14][CH:13]=1>CCO.CC(O)=O.O>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18][N:19]=[C:3]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:2][NH2:1])=[CH:14][CH:13]=1

参加物

6

反応物 2

HCID 11952PhenacylamineHCID 70624(4-Chlorophenyl)hydrazine

生成物 1

HCID 867463512-Aminoacetophenone 4-chlorophenylhydrazone収率 84%

試薬・触媒・溶媒 3

HCID 176Acetic Acid溶媒HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A mixture of 10.43 g 2-aminoacetophenone and 11.0 g 4-chlorophenylhydrazine in 30 ml EtOH and 10 ml HOAc was refluxed for one hour. The cooled reaction mixture was diluted with water and the precipitate was collected, washed with water, and dried to give 16.83 g solid. Recrystallization from methanol gave 3.48 g solid, m.p. 109°-112° C.

後処理

  1. temperaturewas refluxed for one hour
  2. customThe cooled reaction mixture
  3. customthe precipitate was collected
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-fd729e02bed74f7e97efb42406945fc6
出典データセット
uspto-grants-1993_05
特許番号
US05214059

反応ノート

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