Dimethylamine → N,N-Dimethyl-3-(4-nitrophenyl)prop-2-yn-1-amine
反応式
[CH3:1][NH:2][CH3:3].C1(C)C=CC(S(O[CH2:14][C:15]#[C:16][C:17]2[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=2)(=O)=O)=CC=1>ClCCl>[CH3:1][N:2]([CH3:3])[CH2:14][C:15]#[C:16][C:17]1[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=1参加物
4
実験手順
190 ml (4.2 mmol) of dimethylamine dissolved in 2.5 ml of dichloromethane are added dropwise at 0° C. to a solution of 0.7 g (2.1 mmol) of 4-[3-(p-tolylsulphonyloxy)-prop-1-ynyl]-nitrobenzene in 10 ml of dichloromethane. The cooling is stopped and the mixture is stirred for 18 hours at ambient temperature. Then the reaction solution is washed with water and freed from solvent. The residue is chromatographed on silica gel (dichloromethane/methanol=10:1). The product is obtained as an oil.
後処理
- washThen the reaction solution is washed with water
- customThe residue is chromatographed on silica gel (dichloromethane/methanol=10:1)
- customThe product is obtained as an oil
出典と根拠
- ORDレコード
- ord-15b55c7d2fd64ecbb6bbe60feb3c7821
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06855710B2
反応ノート
読み込み中…