Sodium Methoxide → 2-Amino-4-methoxy-6-trifluoromethoxy-1,3,5-triazine
反応式
[CH3:1][O-:2].[Na+].[NH2:4][C:5]1[N:10]=[C:9](F)[N:8]=[C:7]([O:12][C:13]([F:16])([F:15])[F:14])[N:6]=1>CO>[NH2:4][C:5]1[N:10]=[C:9]([O:2][CH3:1])[N:8]=[C:7]([O:12][C:13]([F:16])([F:15])[F:14])[N:6]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
9.1 g (0.0505 mol) of 30% strength sodium methylate were added over the course of 15 minutes to a stirred mixture of 10 g (0.0505 mol) of 2-amino-4-fluoro-6-trifluoromethoxy-1,3,5-triazine and 100 ml of methanol at 0° C. The mixture was stirred at 0° C. for one hour and then concentrated under reduced pressure, taken up in methylene chloride and extracted with water. Drying and concentration yielded 10.5 g (99% of theory) of the title compound of melting point 96°-101° C.
後処理
- concentrationconcentrated under reduced pressure
- extractionextracted with water
- customDrying
- concentrationconcentration
出典と根拠
- ORDレコード
- ord-a242ac4ad4d0450f98e28732b68067a0
- 出典データセット
- uspto-grants-1993_05
- 特許番号
- US05214143
反応ノート
読み込み中…