1,1-Bis(methylthio)-2-nitroethylene → 1-(6-Chloro-3-pyridylmethyl)amino-1-methylthio-2-nitroethylene

HRID 249507ノート

反応式

HRID 249507 の反応式
[CH3:1][S:2][C:3](SC)=[CH:4][N+:5]([O-:7])=[O:6].[Cl:10][C:11]1[N:16]=[CH:15][C:14]([CH2:17][NH2:18])=[CH:13][CH:12]=1>CCO>[Cl:10][C:11]1[N:16]=[CH:15][C:14]([CH2:17][NH:18][C:3]([S:2][CH3:1])=[CH:4][N+:5]([O-:7])=[O:6])=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 836231,1-Bis(methylthio)-2-nitroethyleneHCID 70209275-(Aminomethyl)-2-chloropyridine

生成物 1

HCID 855929321-(6-Chloro-3-pyridylmethyl)amino-1-methylthio-2-nitroethylene収率 47.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To 100 ml of EtOH were added 2.4 g (1.5×10-2 mole) of 1,1-bis(methylthio)-2-nitroethylene and 1.4 g (9.8×10-3 mole) of 6-chloro-3-pyridylmethylamine and the mixture was refluxed for 2 hours. The EtOH was distilled off and the residue was subjected to silica gel column chromatography using CH2Cl2 as an eluent. The procedure gave 1.2 g of the title compound as a pale yellow solid.

後処理

  1. temperaturethe mixture was refluxed for 2 hours
  2. distillationThe EtOH was distilled off

出典と根拠

ORDレコード
ord-620b25440e0a4bdc954f4d867d1ba265
出典データセット
uspto-grants-1993_05
特許番号
US05214152

反応ノート

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