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4-Nitrobenzenesulfonyl chloride → N,N-dimethyl-4-nitrobenzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Nitrobenzenesulfonyl chloride | HCID 7404 | — |
| 反応物 | Dimethylamine, hydrochloride | HCID 10473 | — |
| 反応物 | N,N-Diisopropylmethylamine | HCID 547370 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N,N-dimethyl-4-nitrobenzenesulfonamide | HCID 2747580 | — |
反応手順
4.43 g (20 mmol) of 4-nitrobenzenesulphonic acid chloride are added dropwise at 0° C. to a solution of 2.45 g (30 mmol) of dimethylamine-hydrochloride and 6.46 g (50 mmol) of N,N-diisopropyl-N-methylamine in 30 ml of dichloromethane. The mixture is stirred for 18 hours at ambient temperature. Then the reaction solution is washed with water and dilute hydrochloric acid, dried over magnesium sulphate and evaporated to dryness.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06855710B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-fa275b5c963c420186aa69e2eb377b96 |
| 出典メモ | uspto-grants-2005_02 |