Methyl isothiocyanate → N-methyl-N'-ethyl-N'-(3-pyridylmethyl)thiourea

HRID 249510

反応式

HRID 249510 の反応式
[CH2:1]([NH:3][CH2:4][C:5]1[CH:6]=[N:7][CH:8]=[CH:9][CH:10]=1)[CH3:2].[CH3:11][N:12]=[C:13]=[S:14]>C(OCC)C>[CH3:11][NH:12][C:13]([N:3]([CH2:1][CH3:2])[CH2:4][C:5]1[CH:6]=[N:7][CH:8]=[CH:9][CH:10]=1)=[S:14]

参加物

4

反応物 2

HCID 11167Methyl isothiocyanateHCID 4716480Ethyl[(pyridin-3-yl)methyl]amine

生成物 1

HCID 22450434N-methyl-N'-ethyl-N'-(3-pyridylmethyl)thiourea収率 100.3%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
25 °C

実験手順

In 50 ml of ethyl ether was dissolved 2.4 g of N-ethyl-N-(3-pyridylmethyl)amine followed by addition of 1.3 g of methyl isothiocyanate. The mixture was stirred at room temperature (25° C.) for 1 hour. The resulting precipitate was collected by filtration, washed with a small amount of ethyl ether and dried to give 3.7 g of N-methyl-N'-ethyl-N'-(3-pyridylmethyl)thiourea as white prisms.

後処理

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with a small amount of ethyl ether
  3. customdried

出典と根拠

ORDレコード
ord-44541d504266468eb6785c420de3fa6e
出典データセット
uspto-grants-1993_05
特許番号
US05214152

関連ノート

読み込み中…