Methyl isothiocyanate → 1,1-Dimethyl-4-methyl-2-(3-pyridylmethyl)thiosemicarbazide

HRID 249511ノート

反応式

HRID 249511 の反応式
[CH3:1][N:2]([CH3:11])[NH:3][CH2:4][C:5]1[CH:6]=[N:7][CH:8]=[CH:9][CH:10]=1.[CH3:12][N:13]=[C:14]=[S:15]>C1(C)C=CC=CC=1>[CH3:1][N:2]([CH3:11])[N:3]([CH2:4][C:5]1[CH:6]=[N:7][CH:8]=[CH:9][CH:10]=1)[C:14]([NH:13][CH3:12])=[S:15]

参加物

4

反応物 2

HCID 11167Methyl isothiocyanateHCID 111481501,1-Dimethyl-2-(3-pyridylmethyl)hydrazine

生成物 1

HCID 224505201,1-Dimethyl-4-methyl-2-(3-pyridylmethyl)thiosemicarbazide収率 70.6%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

In 30 ml of toluene was dissolved 2.5 g of 1,1-dimethyl-2-(3-pyridylmethyl)hydrazine followed by addition of 1.2 g of methyl isothiocyanate and the mixture was refluxed for 1 hour. The reaction mixture was concentrated and the resulting crystals are collected by filtration, washed with ethyl ether and dried. The procedure gave 2.6 g of 1,1-dimethyl-4-methyl-2(3-pyridylmethyl) thiosemicarbazide as white prisms.

後処理

  1. temperaturethe mixture was refluxed for 1 hour
  2. concentrationThe reaction mixture was concentrated
  3. filtrationthe resulting crystals are collected by filtration
  4. washwashed with ethyl ether
  5. customdried

出典と根拠

ORDレコード
ord-272a2315106549b891c5feee98b9b66b
出典データセット
uspto-grants-1993_05
特許番号
US05214152

反応ノート

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