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Dimethylformamide → 2-Phenylbutyryl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 2-Phenylbutyric Acid | HCID 7012 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-Phenylbutyryl chloride | HCID 98173 | 68% |
反応手順
Thionyl chloride (0.12 mol) in 60 mL of CH2Cl2 was added to a stirred solution of 2-phenylbutyric acid (16.4 g, 0.10 mol). A catalytic amount of DMF was added and the reaction was allowed to continue overnight at room temperature. The volatiles were removed under vacuum and the residual liquid was vacuum distilled to yield 12.4 g (68%) of 2-phenylbutyryl chloride. IR (neat) 1798 cm-1 (C=O).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05214191 |
| 出典データセット | uspto-grants-1993_05 |
| ORD ID | ord-27d8209bcb5d425b9dd1ab8a3f96bc9c |
| 出典メモ | uspto-grants-1993_05 |