1,2-Bis(2-(tert-butyloxycarbonyl)aminooxyethoxy)ethane → Bis-aminooxy-PEG2

HRID 24957ノート

反応式

HRID 24957 の反応式
C(OC([NH:8][O:9][CH2:10][CH2:11][O:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][NH:19]C(OC(C)(C)C)=O)=O)(C)(C)C>CCOC(C)=O.Cl>[NH2:19][O:18][CH2:17][CH2:16][O:15][CH2:14][CH2:13][O:12][CH2:11][CH2:10][O:9][NH2:8]

参加物

4

反応物 1

HCID 110362781,2-Bis(2-(tert-butyloxycarbonyl)aminooxyethoxy)ethane

生成物 1

HCID 3306142Bis-aminooxy-PEG2収率 90%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 8857Ethyl Acetate溶媒

実験手順

Compound 36 (559 mg, 1.47 mmol) was dissolved in 15 mL of of EtOAc, and HCl gas was bubbled through the solution for 30 minutes. The mixture was concentrated under vacuum to provide 72 mg (90%) of compound 37 as the HCl salt as a sticky residue: 1H NMR (D2O) δ 3.75 (s, 4H), 3.87 (m, 4H), 4.27 (m, 4H); mass spectrum (ES) m/z calculated for C6H17N2O4 (M+H): 181.1. Found: 181.1.

後処理

  1. customwas bubbled through the solution for 30 minutes
  2. concentrationThe mixture was concentrated under vacuum

出典と根拠

ORDレコード
ord-c48368b2745445a4aaf4c31711b1143d
出典データセット
uspto-grants-2005_02
特許番号
US06858210B1

反応ノート

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