関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Propanal | HCID 527 | — |
| 反応物 | Methyl 4-chloroacetoacetate | HCID 36240 | — |
| 触媒 | Piperidine | HCID 8082 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 53697886 | HCID 53697886 | 92.3% |
反応手順
To a solution of 4-chloroacetoacetic acid methyl ester (700 mg : 4.65 mMol.) and propionaldehyde (405 mg : 6.97 mMol.) and acetic acid (28 mg : 0.47 mMol.) in dichloromethane (3 ml) is added a solution of piperidine (24 mg : 0.28 mMol.) in dichloromethane (0.5 ml), and the mixture is stirred at -27° C. for 120 minutes. The reaction mixture is washed with dilute hydrochloric acid and water and concentrated under reduced pressure at lower than 15° C. to give 4-chloro-2-propylideneacetoacetic acid methyl ester (818 mg). Yield: 92%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05214037 |
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| 出典データセット | uspto-grants-1993_05 |
|---|
| ORD ID | ord-5413e0af0a7f4eb0b52b772f16d2a1b8 |
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| 出典メモ | uspto-grants-1993_05 |
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